最近10年来，公司科学家团队始终处在全球单分子成像、单细胞基因组学、高通量测序技术和染色质三维结构科学研究的最前沿，发表了一系列开创性的文章和研究成果，其中Science 1篇，Nature子刊 2篇，Natl Sci Rev（国家科学评论）1篇，PNAS（美国科学院院志）1篇, Angewandte Chemie（德国应用化学）1篇，Nucleic Acid Res 1篇，Chem Sci 1篇，和其他Sci收录期刊文章11篇。
——这些研究致力于开创人类健康的染色质医学时代，发展以染色质三维结构为基础的医学应用，研发针对癌症的first in class的诊断和药物，具有划时代的意义。
——这些研究致力于建立以DNA序列为基础的多尺度和介尺度模型，寻找肿瘤发生发展各阶段的染色质结构变化规律，寻找不同阶段、不同组织、不同癌症的癌细胞染色质结构在多个尺度上的共性，研究癌变中细胞异质性与共性间的联系。
——这些研究致力于寻找癌变中染色质结构变化的共同点，寻找碱基突变和表观遗传性质改变在肿瘤发生中的规律和相互作用，发展以染色质结构和表观遗传修饰为核心的癌症发生发展机制的统一理论框架。
——这些研究致力于发现表观遗传修饰对肿瘤发生发展的影响，发现转录调控模式在癌细胞中的变化，理解肿瘤细胞在免疫反应、细胞间交流及对环境的响应中的变化，发展以染色质结构为切入点的癌症诊断和治疗新方法。
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高毅勤，杨立江，薛玥，王静瑶，何玥颖：
1.Mondal, Manas; Yang, Lijiang; Cai Zhicheng; Patra, Piya; Gao, Yi Qin “A perspective on the molecular simulation of DNAfrom structural and functional aspects”, Chem Sci 12(15), 5390-5409 (2021).
2.Zhou, Rui; Gao, Yi Qin “A DNA Sequence Based Polymer Model for Chromatin Folding”, Int J Mol Sci 22(3), 1328 (2021).
3.Tian, Hao; Yang, Ying; Liu, Sirui; Quan, Hui; Gao, Yi Qin “Toward an understanding of the relation between gene regulation and 3D genome organization”, Quant Bio 8(4), 295-311 (2021).
4.Zhou, Rui; Gao, Yi Qin “Polymer models for the mechanisms of chromatin 3D folding: review and perspective”, Phys Chem Chem Phys 22(36), 20189-20201 (2020).
5.Su, Qian Peter; Zhao, Ziqing Winston; Meng, Luming; Ding, Miao; Zhang, Weiwei; Li, Yongzheng; Liu, Mengzhu; Li, Rongqin; Gao, Yi-Qin; Xie, X. Sunney; Sun, Yujie "Superresolution imaging reveals spatiotemporal propagation of human replication foci mediated by CTCF-organized chromatin structures", PNAS 117(26), 15036-15046 (2020).
6.Quan, Hui; Yang, Ying; Liu, Sirui; Tian, Hao; Xue, Yue; Gao, Yi Qin “Chromatin structure changes during various processes from a DNA sequence view”, Curr Opin Struc Biol 62, 1-8 (2020).
7.Liu, Sirui; Quan, Hui; Tian, Hao; Zhou, Rui, Yang, Lijiang; Gao, Yi Qin “1D Sequence Based 3D Chromatin Phase Separation: Forces, Processes, and Functions”, Acta Phys-Chim Sin 36(1), 1907010(1-15) (2020).
8.Mondal, Manas; Bhattacharyya, Dhananjay; Gao, Yi Qin “Structural properties and influence of solvent on the stability of telomeric four-stranded i-motif DNA”, Phys Chem Chem Phys 21(38), 21549-21560 (2019).
9.Zeng, Hu; Mondal, Manas; Song Ruyi; Zhang, Jun; Xia, Bo; Liu, Menghao; Zhu, Chenxu; He, Bo; Gao, Yi Qin; Yi, Chengqi “Unnatural cytosine bases recognized as thymines by DNA polymerases via the formation of the Watson-Crick geometry”, Angew Chem Int Edit 58(1), 130-133 (2019).
10.Mondal, Manas; Yang, Ying; Yang, Lijiang; Yang, Weitao; Gao, Yi Qin “Role of Conformational Fluctuations of Protein toward Methylation in DNA by Cytosine-5-methyltransferase”, J Chem Theory Comput 14(12), 6679–6689 (2018).
11.Liu, Sirui; Zhang, Ling; Quan, Hui; Tian, Hao; Meng, Luming; Yang, Lijiang; Feng, Huajie; Gao Yi Qin “From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective”, Nucleic Acids Res 46(18), 9367-9383 (2018).
12.Zhang, Ling; Xei, Wen Jun; Liu, Sirui; Meng, Luming; Gu, Chan; Gao, Yi Qin “DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells”, Biophy J 113(7), 1395-1404 (2017).
13.Xie, Wen Jun; Meng, Luming; Liu, Sirui; Zhang, Ling; Cai, Xiaoxia; Gao, Yi Qin " Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle”, Sci Rep 7(1), 2818 (2017).
14.Kim, S.; Brostromer, E.; Xing, D.; Jin, J.; Chong, S.; Ge, H.; Wang, S.; Gu, C.; Yang, L.; Gao, Y. Q.; Su, X.-d.; Sun, Y.; Xie, X. S. "Probing Allostery Through DNA," Science 339(6121), 816-819 (2013).
黄岩谊，王建斌，刘璐：
1.Li, Xiaotian; Liu, Lu, Zhang, Jianyun; Ma, Ming; Sun, Lisha; Li, Xuefen; Zhang, Heyu; Wang, Jianbin; Haung, Yanyi; Li, Tiejun "Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis", Sci China Life Sci published online on June 23, 2021 (2021).
2.Ma, Ming; Liu, Lu; Shi, Ruirui; Zhang, Jianyun; Li, Xiaotian; Li, Xuefen; Bai, Jiaying; Wang, Jianbin; Huang, Yanyi; Li, Tiejun "Copy Number Alteration Profiling Facilitates Differential Diagnosis Between Ossifying Fibroma and Fibrous Dysplasia of the Jaws", Int J Oral Sci published online on June 30, 2021 (2021).
3.Pang, Xinghuo; Ren, Lili, Wu, Shuangsheng; Ma, Wentai; Yang, Jian; Di, Lin; Li, Jie; Xiao, Yan; Kang, Lu; Du, Shichang; Du, Jing; Wang, Jing; Li, Gang; Zhai, Shuguang; Chen, Lijuan; Zhou, Wenxiong; Lai, Shengjie; Gao, Lei; Pan Yang; Wang, Quanyi; Li, Mingkun; Wang, Jianbin; Huang, Yanyi; Wang, Jianwei; COVID-19 Field Response Group, COVID-19 Laboratory Testing Group "Cold-chain food contamination as the possible origin of Covid-19 resurgence in Beijing", Natl Sci Rev 7(12), 1861-1864 (2020).
4.Chen, Zitian; Zhou, Wenxiong; Qiao, Shuo; Kang, Li; Duan, Haifeng; Xie, X. Sunney; Huang, Yanyi "Highly accurate fluorogenic DNA sequencing with information theory-based error correction", Nat Biotechnol 35(12), 1170-1178 (2017).
5.Yao, Jiacheng; Cui, Qionghua; Fan, Wenyi; Ma, Yuling; Chen, Yamei; Liu, Tianyuan; Zhang, Xiannian; Xi, Yiyi; Wang, Chengcheng; Peng, Linna; Luo, Yingying; Lin, Ai; Guo, Wenjia; Lin, Lin; Lin, Yuan; Tan, Wen; Lin, Dongxin; Wu, Chen; Wang, Jianbin “Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer”, Nat Commun 11, 3715 (2020).
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